Faculty Associates

Mallar Bhattacharya, M.D., M.Sc.

Associate Professor, Department of Medicine
Sandler Asthma Basic Research Center
University of California, San Francisco

513 Parnassus Ave, HSE-201
San Francisco, CA 94143-0414

Email: [email protected]

Website:
Bhattacharya Lab

Mallar Bhattacharya is an Associate Professor in the Department of Medicine, Division of Pulmonary and Critical Care. He completed his BA and MD at Harvard University, MSc at University of Oxford, internal medicine residency at Johns Hopkins Hospital, and fellowship training at University of California, San Francisco.

The Bhattacharya laboratory is interested in understanding lung macrophage function under acute inflammatory conditions. The current research is focused on how monocyte-derived macrophages activate adjacent fibroblasts. Using mouse lung slice imaging and genetically-encoded calcium indicators, the lab is testing the role of macrophage-derived factors on fibroblast cytosolic calciumdependent activation responses after injury. A second focus is cellular senescence: specifically, its role in human lung aging and how it is regulated by immune lineages, including iNKTs and macrophages, during lung injury and infection.

Selected Publications:
  1. Sigle RO, Gil SG, Bhattacharya M, Ryan MC, Yang TM, Brown TA, Boutaud A, Miyashita Y, Olerud J, Carter WG. (2004) Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5. Journal of Cell Science. 117(Pt 19): 4481-94. PMID: 15316072.
  2. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay M, Sheppard D. (2012) IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 303(1):L12-19. PMID: 22561460.
  3. Su G, Atakilit A, Li JT, Wu N., Bhattacharya M, Zhu J, Shieh JE, Li E, Sheppard D. (2012) Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med. 185(1):58-66. PMID: 21980034.
  4. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. (2013) Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5. Crit Care Med. Feb;41(2):546-53. PMID: 23263571.
  5. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. (2014) IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. The Journal of Clinical Investigation. 124(11):4895-8. PMID: 25271629.
  6. Bhattacharya M, Kallet RH, Ware LB, Matthay MA. (2016) Negative-Pressure Pulmonary Edema. Chest. 150(4):927-933. PMID: 27063348.
  7. Bhattacharya M. (2016) Macrophages build a wall and the host pays for it. Sci Transl Med. 8(364):ec178.
  8. Bhattacharya, M. (2016) Mesenchymal metamorphosis. Sci Transl. Med. 8(370):370ec202. PMID: 28003541.
  9. Bhattacharya, M. (2017) Could a coffee a day keep the inflammasome away? Sci Transl. Med. 9(376). PMID: 28179502.
  10. Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt Jr. RD, Prakash YS, Bhattacharya M. (2018) Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. Nov 2;3(21). pii: 123578. PMID: 30385725.
  11. Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate A, Butte AJ, Bhattacharya M. (2019) Reference-based analysis of lung single cell RNA-seq reveals a transitional profibrotic macrophage. Nature Immunology. Feb;20(2):163-172. PMID: 30643263.
  12. Alam Z, Devalaraja S, Li M, To TKJ, Folkert IW, Mitchell-Velasquez E, Dang MT, Young P, Wilbur CJ, Silverman MA, Li X, Chen YH, Hernandez PT, Bhattacharyya A, Bhattacharya M, Levine MH, Haldar M. (2020) Counter Regulation of Spic by NF-kB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages. Cell Reports. Jun;31(13):107825. PMID: 32610126.
  13. Arora S, Thompson PJ, Wang Y, Bhattacharyya A, Apostolopoulou H, Hatano R, Naikawadi R, Shah A, Wolters PJ, Koliwad S, Bhattacharya M, Bhushan A. Invariant Natural Killer T cells coordinate removal of senescent cells. Med. In press.
  14. Lee J, Islam MI, Boostanpour K, Aran D, Christenson S, Matthay MA, Eckalbar W, DePianto DJ, Arron JR, Magee L, Bhattacharya S, Matsumoto R, Kubota M, Farber DL, Bhattacharya, Wolters PJ, Bhattacharya M. Molecular programs of fibrotic change in aging human lung. Biorxiv 427195. [Preprint]. January 18, 2021. Available from: https://doi.org/10.1101/2021.01.18.427195.