Faculty Associates

Mallar Bhattacharya, M.D., M.Sc.

Associate Professor, Department of Medicine
Sandler Asthma Basic Research Center

513 Parnassus Ave, HSE-201
San Francisco, CA 94143-0414

Website:
Bhattacharya Lab

Mallar Bhattacharya is an Associate Professor in the Department of Medicine, Division of Pulmonary and Critical Care. He completed his A.B. and M.D. at Harvard University and his M.Sc. at University of Oxford. He completed internal medicine residency at Johns Hopkins Hospital followed by clinical and postdoctoral research training at University of California, San Francisco.

The Bhattacharya laboratory is interested in understanding the molecular mechanisms by which lung macrophages signal to other lineages under acute inflammatory conditions. The current research is focused on interactions between monocyte-derived macrophages and fibroblasts. We seek to determine the functional role of macrophage contacts with fibroblasts in airway and lung interstitial inflammation. The inflammatory “micro-niches” of the lung, whether the interstitial fibrotic niche that develops after lung injury or the bronchovascular cuff where inflammatory cells accumulate after allergen challenge, are rife with cell-cell interactions whose significance is unknown. In our lab, we are using mouse lung slice imaging to unpack this complexity with a focus on pathways regulated by monocyte-derived macrophages. These cells establish contacts with fibroblasts in the first few days after lung injury or with airway allergen challenge. Current projects focus on macrophage-derived signals, including both growth factors and metabolites, that regulate fibroblastic activation with reciprocal effects on lung repair and immunity.

Selected Publications:
  1. Sigle RO, Gil SG, Bhattacharya M, Ryan MC, Yang TM, Brown TA, Boutaud A, Miyashita Y, Olerud J, Carter WG. (2004) Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5. Journal of Cell Science. 117(Pt 19): 4481-94. PMID: 15316072.
  2. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay M, Sheppard D. (2012) IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 303(1):L12-19. PMID: 22561460.
  3. Su G, Atakilit A, Li JT, Wu N., Bhattacharya M, Zhu J, Shieh JE, Li E, Sheppard D. (2012) Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med. 185(1):58-66. PMID: 21980034.
  4. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. (2013) Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5. Crit Care Med. Feb;41(2):546-53. PMID: 23263571.
  5. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. (2014) IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. The Journal of Clinical Investigation. 124(11):4895-8. PMID: 25271629.
  6. Bhattacharya M, Kallet RH, Ware LB, Matthay MA. (2016) Negative-Pressure Pulmonary Edema. Chest. 150(4):927-933. PMID: 27063348.
  7. Bhattacharya M. (2016) Macrophages build a wall and the host pays for it. Sci Transl Med. 8(364):ec178.
  8. Bhattacharya, M. (2016) Mesenchymal metamorphosis. Sci Transl. Med. 8(370):370ec202. PMID: 28003541.
  9. Bhattacharya, M. (2017) Could a coffee a day keep the inflammasome away? Sci Transl. Med. 9(376). PMID: 28179502.
  10. Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt Jr. RD, Prakash YS, Bhattacharya M. (2018) Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. Nov 2;3(21). pii: 123578. PMID: 30385725.
  11. Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate A, Butte AJ, Bhattacharya M. (2019) Reference-based analysis of lung single cell RNA-seq reveals a transitional profibrotic macrophage. Nature Immunology. Feb;20(2):163-172. PMID: 30643263.