Faculty Associates

Erin Gordon, M.D.

Assistant Professor
Division of Pulmonary and Critical Care Medicine
Department of Medicine
University of California, San Francisco

513 Parnassus Ave, HSE-201
San Francisco, CA 94143

Tel: 415-476-9456

Website:
Erin Gordon

Erin Gordon is an Assistant Professor in the Division of Pulmonary and Critical Care Medicine in the Department of Medicine. She completed both her B.S. in Biochemisty at the University of California, Berkeley and M.D. at the University of Southern California. After completing her internship and residency in Internal Medicine at the University of California, San Diego, she pursued fellowship training in Pulmonary and Critical Care Medicine at the University of California, San Francisco. She then completed a postdoctoral research fellowship in the laboratory of Dr. John Fahy in the Airway Clinical Research Center and Cardiovascular Research Institute at the University of California, San Francisco.

The Gordon laboratory is a translational research lab focused on understanding how genetics influence disease heterogeneity in asthma. Our laboratory is particularly focused on understanding the molecular mechanisms that underlie the asthma risk conferred by asthmaassociated genes: IL-33, IL1RL1, and GSDMB. IL-33 is an epithelial derived cytokine and both it and its receptor ST2 (encoded by the IL1RL1 gene) are among the most replicated genome wide association study hits for asthma. We have discovered polymorphisms in these genes that influence gene expression in airway epithelial cells and we are using CRISPR based gene editing to determine the causal polymorphism. We have also found that polymorphisms in these genes are associated with the type 2 high asthma endotype. The GSDMB locus is also among the most replicated asthma genetic loci and the gene encodes a membrane pore forming protein. We have discovered that the gasdermin family of proteins is involved in the secretion of IL-33 from airway epithelial cells. Finally, we have been studying the role of type 2 inflammation and basal cell differentiation in the epithelium of patients with chronic rhinosinusitis with nasal polyps, a disease closely related clinically to severe asthma.

Selected Publications:
  1. Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy JV. Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity. Cell Discov. 2018; 4:7. PMID: 29449961
  2. Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV. Alternative splicing of IL-33 and type 2 inflammation in asthma. PNAS, 2016; 113(31):8765-70. PMCID: PMC4978244
  3. Gordon ED, Locksley RM, Fahy JV. Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25. Am J Respir Crit Care Med. 2016 May 1;193(9):935-6. PMCID: PMC4872659
  4. Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, LachowiczScroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. IL1RL1 Asthma Risk Variants Regulate Airway Type 2 Inflammation. JCI Insight. 2016;1(14):287871. PMCID: PMC5033813
  5. Sweerus K*, Lachowicz-Scroggins ME*, Gordon ED, LaFemina M, Huang X, Parikh M, Fahy JV, Frank JA. Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma. J Allergy Clin ImmunoI, 2016 Apr 20. pii: S0091-6749(16)30089-6. PMCID: PMC5073041
  6. Gordon ED, Sidhu SS, Wang ZE, Woodruff PG, Yuan S, Solon MC, Conway SJ, Huang X, Locksley RM, Fahy JV. A protective role of periostin and TGF-b in IgEmediated allergy and airway hyperresponsiveness. Clinical and Experimental Allergy, 2012. PMCID: PMC3271792