Research Core Directors

Esteban G. Burchard, M.D., M.P.H.

Harry Wm. and Diana V. Hind Distinguished Professor in Pharmaceutical Sciences II
Professor, Department of Bioengineering & Therapeutic Sciences and Medicine

1550 4th St. 5th FL
UCSF Box 2911, RM 584B
San Francisco, CA 94143

Tel: 415-514-9677
Fax: 415-514-4365

Asthma Collaboratory

Esteban González Burchard, M.D., M.P.H., is a physician-scientist with formal training and expertise in pulmonary medicine, epidemiology, molecular genetics, genetic and clinical research. He has led a large research program focusing on minority children and geneenvironment interactions since 2001. Dr. Burchard serves as an advisor to the National Academy of Sciences of the U.S. Congress on gene-environment interactions. Dr. Burchard has expertise in the field of precision medicine and served on the Expert Panel for President Obama’s Precision Medicine Initiative. He initiated and now directs four independent asthma studies in minority children. He has assembled a collaborative team of coinvestigators on several projects with specific expertise in genetics, social and environmental epidemiology.

Dr. Esteban Burchard directs the Asthma Genetics Core Facility, now named the Asthma Collaboratory, which is now the largest annoted gene biorepository from minority populations with asthma in the world. The Asthma Biobank is open to reputable scientists seeking to assess genetic risk for variants in populations of interest or to extend findings made in animal models to suggest potential mechanistic involvement in human asthma. The Asthma Collaboratory has met continued goals to expand the numbers of patient samples; to extend the numbers of collaborators both nationally and internationally who use the database; and to continue to spearhead genetic studies in minority populations with asthma. The Burchard lab has led efforts to identify genetic modifiers of drugs used in asthma that might contribute to the poorer response in a number of ethnic populations and more recently is leading efforts to find biomarkers for differents subsets of asthma as defined by presentation or response to therapy. These efforts have contributed to over 20 publications in the past 2 years with numerous collaborators and trainees, and successful competition for extramural funding. Dr. Burchard served on President Obama’s Precision Medicine Initiative and has begun efforts to prepare a US-wide Asthma Genetics Consortium grant funded by the NIH.

Dr. Burchard’s team is taking a comprehensive approach to studying asthma and related phenotypes in minority children by focusing on genetic, social and environmental risk factors with the goal of creating innovative therapies and identifying targets for public health inventions. Dr. Burchard’s team was the first to leverage genetic ancestry to identify novel genetic and environmental risk factors for disease and poor drug response. Dr. Burchard’s laboratory recently completed the largest genome-wide association studies (GWAS) and admixture-mapping scans of asthma in minority children and total IgE in the United States. Dr. Burchard and his team published the largest air pollution and genome-wide study of asthma in minority children. His research has been seminal in elucidating the pathogenesis of asthma and asthma related traits in minority populations.

Lab Objectives:
  1. Focus on the interplay between genes and their social and physical environments to determine the root causes of asthma health disparities among different populations locally and globally.
  2. Identify risk factors associated with poor drug response, which we hope will lead the way to better therapies for all populations.
  3. Collaborate with other researchers in the field and share our results and strengths.
Selected Publications:
  1. White MJ, Risse-Adams O, Goddard P, Contreras MG, Adams J, Hu D, Eng C, Oh SS, Davis A, Meade K, Brigino-Buenaventura E, LeNoir MA, Bibbins-Domingo K, Pino- Yanes M, Burchard EG. Novel genetic risk factors for asthma in African American children: Precision Medicine and the SAGE II Study. Immunogenetics. 2016 May 3. PubMed PMID: 27142222.
  2. Oh SS, Galanter J, Thakur N, Pino-Yanes M, Barcelo NE, White MJ, de Bruin DM, Greenblatt RM, Bibbins-Domingo K, Wu AH, Borrell LN, Gunter C, Powe NR, Burchard EG. Diversity in Clinical and Biomedical Research: A Promise Yet to Be Fulfilled. PLoS Med. 2015 Dec 15; 12(12):e1001918. PubMed PMID: 26671224; PubMed Central PMCID: PMC4679830.
  3. Brehm JM, Man Tse S, Croteau-Chonka DC, Forno E, Litonjua AA, Raby BA, Chen W, Yan Q, Boutaoui N, Acosta-Pérez E, Avila L, Weiss ST, Soto-Quiros M, Cloutier MM, Hu D, Pino-Yanes M, Wenzel SE, Spear ML, Kolls JK, Burchard EG, Canino G, Celedón JC, A Genome-Wide Association Study of Post-bronchodilator Lung Function in Children with Asthma. AJRCCM, Vol. 192, No. 5, September 1, 2015: 634-7 PMID: 26325155.
  4. Pino-Yanes M, Gignoux CR, Galanter JM, Levin AM, Campbell CD, Eng C, Huntsman S, Nishimura KK, Gourraud PA, Mohajeri K, O'Roak BJ, Hu D, Mathias RA, Nguyen EA,Roth LA, Padhukasahasram B, Moreno-Estrada A, Sandoval K, Winkler CA, Lurmann F, Davis A, Farber HJ, Meade K, Avila PC, Serebrisky D, Chapela R, Ford JG, LenoirMA, Thyne SM, Brigino-Buenaventura E, Borrell LN, Rodriguez-Cintron W, Sen S,Kumar R, Rodriguez-Santana JR, Bustamante CD, Martinez FD, Raby BA, Weiss ST,Nicolae DL, Ober C, Meyers DA, Bleecker ER, Mack SJ, Hernandez RD, Eichler EE,Barnes KC, Williams LK, Torgerson DG, Burchard EG. Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. J Allergy Clin Immunol. 2015 Jun;135(6):1502-10 PMID: 25488688; PMCID: PMC4458233.
  5. McGarry ME, Castellanos E, Thakur N, Oh SS, Eng C, Davis A, Meade K, LeNoir MA, Avila PC, Farber HJ, Serebrisky D, Brigino-Buenaventura E, Rodriguez-Cintron W, Kumar R, Bibbins-Domingo K, Thyne SM, Sen S, Rodriguez-Santana JR, Borrell LN, Burchard EG. Obesity and Bronchodilator Response in African-American and Hispanic Children and Adolescents with Asthma. Chest. 2015 Mar 5. PMID: 25742612.
  6. Andrés Moreno-Estrada, Christopher R. Gignoux, (35 authors), Irma Silva-Zolezzi,* Esteban Gonzalez Burchard, *Carlos D. Bustamante. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits. Science. 2014 Jun 13; 344(6189):1280-1285 PMID: 24926019 PMCID: PMC4156478. *Shared senior authors.
  7. Medical research: Missing patients. Burchard EGNature. 2014 Sep 18; 513 (7518):301-2. PMID: 25230631.
  8. Pino-Yanes M, Thakur N, (37 authors), Burchard EG. Genetic ancestry influences asthma susceptibility and lung function among Latinos. JACI. 2014 Sep 13. PMID: 25301036. PMCID: PMC4289103.
  9. Nishimura, K.K., Galanter, J.M., (19 Authors), Burchard, E.G Early Life Air Pollution and Asthma Risk in Minority Children: The GALA II & SAGE II Studies. AJRCCM. 2013 Aug. 1; 188(3):309-18. PMID: 23684070. PMCID: PMC3778732.
  10. Kumar R*, Seibold MA*, Aldrich MCF*, Williams KL*, (23 authors), Burchard EG.*Equal contributions. Genetic ancestry in lung-function predictions. NEJM. 2010 Jul 22; 363(4):321-30. PMCID: PMC2922981.
  11. Seibold MA, Reese TA (21 authors), Burchard EG. Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. JBC. 2009; 284(29):19650-8 PMCID: PMC2740590.
  12. Choudhry S., Ung N, (28 authors), Burchard EG. Pharmacogenetic Differences in Response to Bronchodilators between Puerto Rican and Mexican Asthmatics. AJRCCM. 2005; 171(6):563-70 PMID: 15557128.
  13. Burchard EG, Avila PC, (23 authors), Silverman EK; Lower Bronchodilator Responsiveness in Puerto Rican than in Mexican Asthmatic Subjects. AJRCCM. 2004; 169(3):386-92. PMID: 14617512.