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2015 Annual Report

2015 Annual Report

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Sandler Asthma Basic Research Center

Mission Statement

The Sandler Asthma Basic Research Center (SABRE Center) at UCSF is an investigative unit dedicated to basic research discovery in asthma. Founded in 1999, the SABRE Center was nucleated by a group of five basic scientists supported by advanced technology cores and linked with the larger scientific community through Center Grants and Program Project Grants focused around asthma research. With successes and growth, the Center subsequently aligned with the Airway Clinical Research Center at UCSF to facilitate an increased focus on human studies. Our mission remains to be a progressive, nimble, transformative scientific group that will pioneer discovery in asthma research to accomplish our vision of a world free of asthma. The SABRE Center is made possible through the generous support of the Sandler Foundation.

Summary of Accomplishments over the Past Year

The SABRE Center has evolved into a productive disease-oriented research enterprise within the greater UCSF scientific community. The past year was marked by maturation and growth as the Center expanded and began to take on a greater presence in the arena of human disease. Notable accomplishments included:

  1. Implementation of a Strategic Plan to transform the Center to a more human disease-centric platform over a 3-5 year period. The Plan includes a stepwise reduction in funding to basic animal core technologies while expanding outreach into areas of sample collection, patient recruitment and technology development to provide resources for a cadre of young investigators in training.
  2. Dr. Jeoung-Sook Shin, the last of our original young faculty recruits to the SABRE Center, was awarded an NIH R01 grant for her work and was advanced to tenure at UCSF.
  3. Dr. Laurence Cheng, an M.D./Ph.D. allergist, was recruited to the SABRE Center to study basophil and mast cell biology in asthma. Recruited as an Assistant Professor in Pediatrics, Dr. Cheng was awarded the Mary E. and Oscar L. Frick Endowed Chair in Pediatric Allergy in the fall of 2014.
  4. Dr. Mark Ansel, one of our initial recruits, received accelerated promotion to tenure and was bestowed a state FTE position in the UC system.
  5. SABRE Center investigators continued to publish high-impact manuscripts in competitive journals and to compete successfully for extramural funds despite the difficult NIH payline. Increasingly, these studies have begun to work with and focus on human patients and materials.

We look forward to ongoing successes in the coming year as we continue with our mission to conquer asthma.